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What antibiotics work for cystic acne? Nonprescription Treatment for Acne Benzoyl peroxide. Sulfur. Topical clindamycin and erythromycin are antibiotics that are also anti-inflammatory drugs and are effective against a number of bacteria. For severe cystic acne, isotretinoin is the most effective therapy.
Why my acne is not going away? When too much sebum is produced, the oil can clog up pores and hair follicles. This attracts bacteria, which leads to acne. Greasy foods, chocolate, and dairy don't cause acne but can exacerbate it. So if you're on a strict skincare regimen but your skin isn't clearing up, you should take a look at your diet.

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